2009/09/09

Chemicals in medicines

Chemicals in medicines

The words ‘medicine’ and 'drug' are often used in our country to mean the same substances: any substance, manufactured artificially, which can help recovery from sickness, relieve symptoms or modify a natural process in the body. A medicine is often a mixture of several chemical compounds. Even if it has only one active component compound often other substances are used as fillers or binders to give it bulk. Chemistry, the science related to chemical substances, provides us the tools to make and study the substances that are the constituents of almost all medicines. The past hundred years or so, ever since the advent of organic chemistry, many chemical compounds have been discovered in nature that are effective for curing diseases. Modern chemistry has also made it possible to synthesize several medicines using methods of organic chemistry

The most common medicines can be classified into few groups, e.g. antibiotics; antiseptics; analgesics; and antipyretics etc. While an antibiotic is a drug that kills or prevents the growth of bacteria, an analgesic is often used to relieve pain

There are very many medicines that come under each of these groups. Often several chemical compounds that make a particular group of medicines, say antibiotics have similar chemical structure. Since the medicines in a particular group are effective for treating a particular type of ailment or disease, their mode of action can also be very similar. But, the methods used to isolate a medicine from its natural sources or to synthesize it are most often very different

In this project, I have tried to find out the relationships between chemical structures of medicines in three groups of medicines, viz. Antibiotics; Antipyretics and Analgesics. I have also explored the mode of action of these groups of medicines and the chemical methods used to make them available

Antibiotics

Our body and our domestic animals, can serve as hosts to a wide variety of disease-causing organisms (pathogens): These are
bacteria
viruses
fungi
protozoon’s

Here we will examine only those chemicals that are used to combat bacterial pathogens An antibiotic (Greek anti, "against"; bios, "life"), is a chemical substance produced by one organism that is destructive to another. This process traditionally has been called antibiosis and is the opposite of symbiosis. More specifically, an antibiotic is a type of chemotherapeutic agent that has a toxic effect on certain types of disease-producing microorganisms without acting dangerously on the patient. The definition most used for antibiotics is: any substance produced by a microorganism which harms or kills another microorganism. However, antibiotics DO NOT harm viruses. Doctors often prescribe antibiotics when you may have a viral infection because of the possibility that you may also acquire a bacterial infection because you are so ill with a virus - being ill places a person at risk for certain bacterial infections that are normally handled without any problem
The overwhelming majority of antibiotic substances are natural products that certain bacteria and fungi (molds) produce and send outside of their cells. About 90% of the antibiotics in use today, are isolated from bacteria. There are a few antibiotics, however, which are completely synthetic... that is, are made from scratch in the laboratory. These particular antibiotics are designed to inhibit some process previously identified to be completely unique to bacteria, and necessary for the bacterium to remain alive
An antibiotic can be most often classified into any one of the following categories of chemical compound
Aminoglycosides
Glycopeptides
Beta Lactams also known as Penicillins
Tetracycline
Quinolines
Sulfonamides
Aminoglycosides
Aminoglycosides are antibiotics that are often administered into veins or muscle to treat serious bacterial infections. Some aminoglycosides are also used orally to treat intestinal infections or topically to treat eye infections. Some very popular examples of this group of antibiotics are
Examples are
Streptomycin
Kanamycin
Neomycin
Gentamycin

Glycopeptides
Glycopeptide antibiotics are a class of antibiotic drugs. They consist of a glycosylated cyclic or polycyclic nonribosomal peptide. Important glycopeptide antibiotics include vancomycin, teicoplanin, ramoplanin, and decaplanin
This class of drugs inhibit the synthesis of cell walls in susceptible microbes by inhibiting peptidoglycan synthesis. Due to their toxicity, their use is restricted to those patients who are critically ill or who have a demonstrated hypersensitivity to the β-lactams

Penicillins are one major class of antibiotics. They are used to treat strep throat and countless other infections. Examples of various kinds of penicillins include
Amoxicillin
Ampicillin
Azlocillin
Carbenicillin
Cloxacillin
Dicloxacillin
Flucloxacillin
Mezlocillin
Nafcillin
Penicillin
Common structural features of Beta-Lactams; (The beta-lactams get their name from the characteristic ring structure — shown here in blue — that they all share. (The green arrow shows the bond that is broken by a class of enzymes called beta-lactamases that are synthesized by many penicillin-resistant bacteria)
Tetracycline
Tetracyclines are another category of antibiotics. In addition to being used to treat infections, they are often used to manage acne. A few of the tetracyclines frequently used are
§ Achromycin V® (Tetracycline)
§ Minocin® (Minocycline)
§ Vibramycin® (Doxycycline)

The chemical structure of most tetracycline is related to the following structure. One can see that the name is derived from the fact that it is madeup of four rings (cycles
Examples of commonly used tetracycline’s include
Demeclocycline
Doxycycline
Minocycline
Oxytetracycline
Tetracycline

Quinolones
The quinolones are a family of broad-spectrum antibiotics. The parent of the group is nalidixic acid. The majority of quinolones in clinical use belong to the subset of fluoroquinolones, which have a fluoro group attached the central ring system. Quinolones and fluoroquinolones are bactericidal drugs, actively killing bacteria. Quinolones inhibit the bacterial DNA gyrase or the topoisomerase II enzyme, thereby inhibiting DNA replication and transcription

Sulfonamides
Sulfonamide drugs (known widely as "sulfa drugs") were the first antibacterial antibiotics, and paved the way for the antibiotic revolution in medicine. The first sulfonamide was trade named Prontosil, which is a prodrug. Experiments with Prontosil began in 1932 in the laboratories of the Bayer Corporation, a component of the huge German chemical trust IG Farben. The dye-based drug was synthesized by Bayer chemist Josef Klarer and tested in animals under the direction of physician/researcher Gerhard Domagk. Domagk quickly won the 1939 Nobel Prize in Medicine and Physiology, an honor that Hitler forbade him to accept
Some examples of sulfonamide antibiotics are
Mafenide
Prontosil
Sulfacetamide
Sulfamethizole
Sulfanilimide
Sulfasalazine
Sulfisoxazole
Trimethoprim
Trimethoprim-Sulfamethoxazole (Co-trimoxazole) (TMP-SMX)

Analgesics
Analgesics are medicines that help to control pain and reduce fever. An analgesic (colloquially known as a painkiller) is any member of the diverse group of drugs used to relieve pain (achieve analgesia). This derives from Greek an-, "without", and -algia, "pain". Examples of analgesics that are available over the counter are: aspirin, acetaminophen, ibuprofen, ketoprofen and naproxen sodium. Some analgesics contain a combination of ingredients in one pill, such as aspirin, acetaminophen and caffeine
Analgesics act in various ways on the peripheral and central nervous system; they include paracetamol (acetaminophen), the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, narcotic drugs such as morphine, synthetic drugs with narcotic properties such as tramadol, and various others. Some other classes of drugs not normally considered analgesics are used to treat neurop athic pain syndromes; these include tricyclic antidepressants and anticonvulsants
Thus acetylsalicylic acid (commonly known as aspirin) is a salicylate

Aspirin is commercially synthesized using a two-step process. First, phenol (generally extracted from coal tar) is treated with a sodium base generating sodium phenoxide, which is then reacted with carbon dioxide under high temperature and pressure to yield salicylate, which is acidified, yielding salicylic acid. This process is known as the Kolbe-Schmitt reaction


Antiseptics

Antiseptics are antimicrobial substances that are applied to living tissue/skin to to reduce the possibility of infection, sepsis, or putrefaction. They should generally be distinguished from antibiotics that destroy microorganisms within the body, and from disinfectants, which destroy microorganisms found on non-living objects. Some antiseptics are true germicides, capable of destroying microbes (bacteriocidal), whilst others are bacteriostatic and only prevent or inhibit their growth. Antibacterials are antiseptics that only act against bacteria
Some chemical compounds/groups of chemical substances that are often used as antiseptics are
Alcohols
Most commonly used are ethanol (60-90%), 1-propanol (60-70%) and 2-propanol/isopropanol (70-80%) or mixtures of these alcohols. They are commonly reffered to as "surgical alcohol". Used to disinfect the skin before injections are given, often along with iodine (tincture of iodine) or some cationic surfactants (benzalkonium chloride 0.05 - 0.5%, chlorhexidine 0.2 - 4.0% or octenidine dihydrochloride 0.1 - 2.0%)

Quaternary ammonium compounds
They include the chemicals benzalkonium chloride (BAC), cetyl trimethylammonium bromide (CTMB), cetylpyridinium chloride (Cetrim), cetylpyridinium chloride (CPC) and benzethonium chloride (BZT). Benzalkonium chloride is used in some pre-operative skin disinfectants (conc. 0.05 - 0.5%) and antiseptic towels. The antimicrobial activity of Quats is inactivated by anionic surfactants, such as soaps. Related disinfectants include chlorhexidine and octenidine

Boric acid
Used in suppositories to treat yeast infections of the vagina, in eyewashes, and as an antiviral to shorten the duration of cold sore attacks. Put into creams for burns. Also common in trace amounts in eye contact solution. Though it is popularly known as an antiseptic, it is in reality only a soothing fluid, and bacteria will flourish comfortably in contact with it

Chlorhexidine Gluconate
A biguanidine derivative, used in concentrations of 0.5 - 4.0% alone or in lower concentrations in combination with other compounds, such as alcohols. Used as a skin antiseptic and to treat inflammation of the gums (gingivitis). The microbicidal action is somewhat slow

Hydrogen peroxide
Used as a 6% (20Vols) solution to clean and deodorise wounds and ulcers. More common 1% or 2% solutions of hydrogen peroxide have been used in household first aid for scrapes, etc. However, even this less potent form is no longer recommended for typical wound care as the strong oxidization causes scar formation and increases healing time. Gentle washing with mild soap and water or rinsing a scrape with sterile saline is a better practice

Iodine
Usually used in an alcoholic solution (called tincture of iodine) or as Lugol's iodine solution as a pre- and post-operative antiseptic. No longer recommended to disinfect minor wounds because it induces scar tissue formation and increases healing time. Gentle washing with mild soap and water or rinsing a scrape with sterile saline is a better practice. Novel iodine antiseptics containing iodopovidone/PVP-I (an iodophor, complex of povidone, a water-soluble polymer, with triiodide anions I3-, containing about 10% of active iodine, with the commercial name Betadine) are far better tolerated, don't affect wound healing negativelly and leave a depot of active iodine, creating the so-called "remanent," or persistent, effect. The great advantage of iodine antiseptics is the widest scope of antimicrobial activity, killing all principial pathogenes and given enough time even spores, which are considered to be the most difficult form of microorganisms to be inactivated by disinfectants and antiseptics

Mercurochrome
Not recognized as safe and effective by the U.S. Food and Drug Administration (FDA) due to concerns about its mercury content. Another obsolete organomercury antiseptics include bis-(fenylmercury) monohydrogenborate (Famosept)

Phenol (carbolic acid) compounds
Phenol is germicidal in strong solution, inhibitory in weaker ones. Used as a "scrub" for pre-operative hand cleansing. Used in the form of a powder as an antiseptic baby powder, where it is dusted onto the belly button as it heals. Also used in mouthwashes and throat lozenges, where it has a methadone-like painkilling effect as well as an antiseptic one. Example: TCP. Other phenolic antiseptics include historically important, but today rarely used (sometimes in dental surgery) thymol, today obsolete hexachlorophene, still used triclosan and sodium 3,5-dibromo-4-hydroxybenzenesulfonate (Dibromol)

Sodium chloride
Used as a general cleanser. Also used as an antiseptic mouthwash. Only a weak antiseptic effect, due to hyperosmolality of the solution above 0.9%

Sodium hypochlorite
Used in the past, diluted, neutralised and combined with potassium permanganate in the Daquin's solution. Nowadays used only as disinfectant


How Antibiotics act.
Antibiotics attack a metabolic pathway found in the bacterium but not in the host. This is not an insurmountable problem for bacterial pathogens because they differ in many respects from eukaryotes.
Thus pencillins (beta-lactams) work by interfering with the synthesis of the bacterial cell wall — a structure that is not found in eukaryotes. The walls of bacteria are made of a complex polymeric material called peptidoglycan. It contains both amino acids and amino sugars. The amino sugars are of two kinds
N-acetylglucosamine (NAG) and its close relative
N-acetylmuramic acid (NAM).
These two form a linear polymer of NAG alternating with NAM. They are linked by a glycosidic bond between the #1 and #4 carbons (this is the linkage attacked by lysozyme) and are oriented in the same way they are in cellulose. Side chains containing 4 or 5 amino acids are attached to each NAM. These form covalent bonds with amino acids in adjacent chains. The bonds may
be direct to the next chain or
include additional peptide cross bridges (e.g., 5 glycine residues) which
extend to chains in the same plane (shown here) as well as to chains above and below

This elaborate, covalently cross-linked structure provides the great strength of the cell wall. It also leads to the remarkable conclusion that the bacterial cell wall meets the definition of a single molecule!
The beta-lactam antibiotics bind to and inhibit enzymes needed for the synthesis of the peptidoglycan wall. While they have little effect on resting bacteria, they are lethal to dividing bacteria as defective walls cannot protect the organism form bursting in hypotonic surroundings

The aminoglycosides bind to the 30S subunit of the bacterial ribosome, because the bacterial ribosome differs in several ways from the eukaryotic ribosome and thus interferes with the formation of the initiation complex , causing misreading of the mRNA

Tetracyclines also bind to the 30S subunit of the bacterial ribosome. They prevent the transfer of activated amino acids to the ribosome so protein synthesis is halted

The fluoroquinolones block the action of two bacterial topoisomerases — enzymes that relieve the coils that form in DNA when the helix is being opened in preparation for replication or transcription or repair

The mode of action of Sulfonamides is a bit different. Both bacteria and their human hosts require folic acid for nucleic acid synthesis (it is converted into prunes and thymidine) as well as protein synthesis (precursor of the amino acids methionine and glycine). However, bacteria synthesize their folic acid starting with para-aminobenzoic acid (PABA), while we must ingest our folic acid already formed; that is, for us it is a vitamin.
Sulfanilamide, and the other sulfa drugs, are analogs of PABA; they compete with PABA and, when chosen, block the synthesis of folic acid. Mammals ignore PABA and its analogs and thus can tolerate sulfa drugs

Production of antibiotics

Since the first pioneering efforts of Florey and Chain in 1939, the importance of antibiotics to medicine has led to much research into discovering and producing them. The process of production usually involves screening of wide ranges of microorganisms, testing and modification. Production is carried out using fermentation; a process that is important in anaerobic conditions when there is no oxidative phosphorylation to maintain the production of adenosine triphosphate (ATP) by glycolysis


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  40. “I was diagnosed with HSV-2 Four years ago. I hardly had any symptoms until now. I was not in a sexual relationship but this week I had s ex after my menstrual cycle. I had my first outbreak, it was horrible. I felt so depressed. I had all kinds of blisters in private places. Very very painful, it was hard to walk, sit, sleep, or go to the bathroom. I searched the web for treatment. First I tried tea tree oil, that was too harsh down there. Then I took 6,000 mg of Lysine, that did not help at all. Took 3,000 mg vitamin C, nothing. I felt that white vinegar helped a bit and cornstarch was soothing. I took 2 Epsom salt baths a day and that was soothing also. The only thing that helped was the natural herbal medicine I later ordered from Dr. Azu after some research. And the symptoms went away right away.” I'm so happy to have come in contact with doctor Azu. Thanks so much. You can also get help from him through his cell phone on +2347087313747 or Email: dr.azuherbalhome@gmail.com .

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